Very few agree that pediatricians and GPs are aware and informed about rare disease. Even half perceive specialists as lacking in up-to- date knowledge and expertise. Consensus shows that extraordinarily little education time is provided or expected on understanding the daily challenges for those managing with rare disease. Feedback from specialists attending conferences on being asked how they are, how they are educating younger physicians on rare diseases, provides no satisfactory answer. A center with specialists of diverse backgrounds working on the same problem opens doors for collaboration and optimal results. Treating a patient with a rare disease goes beyond access to rare and expensive drugs. Rare disease centers would address a wide variety of gaps that exist in the diagnosis and treatment of rare diseases.